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The # 1 recommended topical

Biofreeze pain relieving products are the most recommended topical analgesic by hands-on health professionals for over 15 years.

Its is the topical of choice for massage therapists, chiropractors, physical therapists and more.

Biofreeze provides temporary relief of minor aches and pains related to:


  • Back, shoulder and neck strains
  • Knee, Hip and Elbow joint discomfort
  • Muscle sprains and strains

How it works

Traditional thinking is that the pain-relieving mechanism of action of menthol – the active ingredient in Biofreeze Pain Reliever – results from a counter-irritant effect. Simply put, a counter-irritant has an effect of overriding noxious pain signals traveling to the brain through a process modulated between pain-transmitting and non-pain transmitting neurons. This process, known as “gate control” or “gating,” was first described by Melzak and Wall.

Gate control theory is based on the understanding that pain is transmitted by two kinds of afferent nerve fibers. One is the larger myelinated A-delta fiber, which carries quick, intense-pain messages. The other is the smaller, unmyelinated “C” fiber, which transmits throbbing, chronic pain. A third type of nerve fiber, called A-beta, is “nonnociceptive,” meaning it does not transmit pain stimuli. The gate control theory asserts that signals transmitted by the A-delta and C pain fibers can be thwarted by the activation/stimulation of the nonnociceptive A-beta fibers and thus inhibit an individual’s perception of pain.

More recently, laboratory researchers have discovered that menthol stimulates the TRPM8 cold receptors. Even though it has long been accepted that cooling and cold can induce analgesia it has been a poorly understood mechanism. As scientists have continued to isolate these specific heat-sensitive transient receptor potential (TRP) channels within our sensory neurons we are now able to have a much better understanding of the body’s cutaneous temperature detection. With the isolation and further study of these specific TRPM8 receptors there is stronger evidence supporting the benefits achieved with the cooling effect of menthol in functioning as a topical analgesic while activating these receptors and the resulting consequent pain relief.

Frequently Asked Questions

Biofreeze Pain Reliever provides temporary relief from minor aches and pains of sore muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains. Apply Biofreeze Pain Reliever to the affected area not more than 4 times daily; massage not necessary.

No, you do not need a prescription, nor do you need to be a patient of a healthcare professional in your area to purchase Biofreeze from them. Biofreeze is only available through authorized dealers. Biofreeze is not available through retail outlets or pharmacy locations.

Biofreeze products are classified as topical analgesics, which work through a ‘counter irritant’ mechanism. This means that the menthol in Biofreeze creates a sensation that overrides pain signals to the brain. This process is known as ‘Gate Control Theory’, where nerve impulses from one stimulus block the nerves containing pain signals to the brain. Recent research also suggests that menthol may stimulate cold receptors in the skin that may help regulate pain as well.

 Yes, Biofreeze is the #1 used and recommended topical pain reliever by chiropractors, massage therapists, physical therapists, and podiatrists.

Biofreeze can be used up to four times a day.

Also known as ‘cold therapy’, cryotherapy is the application of cold to temporarily relieve pain. The related term cryokinetics refers to the pairing of pain-relieving cryotherapy with exercise. This cooling and re-warming of tissue stimulates the return of blood flow to the affected areas.

The most common form of cryotherapy is ice. Biofreeze produces the same sensation of cold that accompanies icing. But unlike ice, Biofreeze products allow you to remain active during treatment.

Yes, Biofreeze conducts all FDA required studies such as: skin sensitization, drug stability, and process validation testing. We also conduct an additional battery of tests in our laboratory. Lastly, we conduct studies with clinicians to further understand our products.

Yes, you can take the 2 fl oz spray, 3 fl oz roll-on, Max Strength Wipes, and 5 mL sample packet on an airplane.

Biofreeze is available in a 4 fl oz gel tube, 4 fl oz gel tube with hands-free applicator, 2 fl oz & 4 fl oz spray, 3 fl oz roll-on, 8 ml wipe, or 5 ml trial packets.

o The 4 fl oz Biofreeze gel tube is particularly well-suited for hands-on massage applications of larger muscle areas.

o The 4 fl oz Biofreeze gel tube with hands-free applicator allows the user to apply the gel either hands-free or hands-on. The delicate sponge applicator is perfect for even application of Biofreeze on sore joint, especially smaller joints like the knuckles.

o  The 3 fl oz Biofreeze roll-on is a hands-free application with the added benefit of the roller ball that can be used to massage painful muscles and stimulate trigger points in the affected area.

o The 2 fl oz & 4 fl oz Biofreeze Spray is hands-free application designed for hard to reach areas and is particularly beneficial for conditions involving minor neck and back pain.

o The Biofreeze maximum strength wipe is the strongest Biofreeze available. The single-use disposable wipe is strong enough for the deepest pain, yet small enough to fit in your pocket.

o The 5 mL packets are available in boxes of 100 and are most commonly used for traveling purposes, when it is inconvenient to carry one of the larger sizes.

The larger sizes of Biofreeze are designed for in clinic use.  Please consult a healthcare practitioner regarding the purchase of professional sizes.

Biofreeze is an over the counter topical analgesic pain relieving gel used to provide temporary relief from minor aches and pains of sore muscles and joints associated with simple backache, arthritis, bruises, strains and sprains. It is labeled according to the Food and Drug Administration (FDA) regulations regarding topical analgesics. All ingredients, directions for use, and product warnings are listed on the label.

Please remember that Biofreeze is a topical pain reliever, not a cure to an underlying condition. It provides temporary pain relief. If you have any questions regarding the product or its use, please consult your healthcare Professional. If condition worsens or symptoms persist for more than 7 days consult a doctor.

The product’s shelf life is 2 years. The expiration date can be located on the package of Biofreeze Pain Relieving Product.

The active ingredient in Biofreeze is menthol.

Biofreeze was first introduced in 1991 by a healthcare practitioner that was searching for a way to help his grandmother manage her arthritis pain. Today, Biofreeze products provide relief to countless arthritis sufferers. But the pain reliever’s unique, cooling formulation is also comforting to sore muscles and muscle sprains; easing back shoulder and neck pain; reducing painful ankle, knee, hip, and elbow joints and helping to lessen the effects of muscular strain.

Ilex is an inactive ingredient in Biofreeze used to achieve a non greasy texture.

Biofreeze is only a topical pain reliever and has a low potential for absorption. We do suggest that you always check with your healthcare professional before using Biofreeze.

Consult a healthcare professional before use.

The color additives used in Biofreeze are approved by the USDA for general use in cosmetics and over the counter medications. They are also used in many of your favorite foods that you eat every day.

No, you should never use a heating pad while using Biofreeze. Biofreeze works by causing a cooling effect, not heat. By using a heating pad in conjunction with Biofreeze, you may cause serious injury to yourself. You may not be able to tell how hot the heating pad is on the problem area, even possibly causing yourself to experience severe blistering.

No. You should not wrap or bandage the area where Biofreeze is being applied.

Tell your patient to rinse his/her eyes with lukewarm water or to take a warm shower with the shower water hitting their forehead and running down through their eyes. Do this for 15 minutes. If problem persists, have them see a physician and be sure they take the Biofreeze with them.

Biofreeze is not intended for use in these types of situations.

Biofreeze is not intended for use in these types of situations.

Biofreeze is not intended for this use.

If your child placed it in mouth but did not swallow, flood mouth with lukewarm water and rinse out mouth thoroughly.

If your child swallowed Biofreeze, drink several glasses of water, and DO NOT induce vomiting. If a large amount is consumed, contact a Poison Control Center immediately.

Pet – Contact your veterinarian immediately. Animals will not drink water on command. Animals have a highly developed sense of smell and the menthol, camphor and alcohol contact will warn them away from ingesting the product. It overwhelms their sense of smell and therefore, does not appear as food or something appetizing. Biofreeze should not hurt them, but it is always best to contact your veterinarian in any instance where Biofreeze has been ingested by your pet.

No, do not apply to wounds or damaged skin.

Take a tepid (warm) bath with one cup of Arm and Hammer baking soda, or other brand of baking soda. Relax for at least 20 minutes. If rash persists, contact your physician.

Yes, The FDA registers the facilities that manufacture Biofreeze. Please refer to the National Drug Code number that is on every Biofreeze product. This number represents to the FDA, our product/brand and the actual size of the container.

Yes, Biofreeze is a topical pain reliever has a low potential for absorption. Diabetes is a disease in which the body cannot use sugar normally. When diagnosed with this particular ailment, you must be extremely cautious when using any OTC medications. There are certain ingredients in OTC medications that do go in to the bloodstream that can cause a severe reaction to the Diabetic patient. Biofreeze does not contain any of these ingredients and can often be used by the diabetic patient. However, please consult with your healthcare professional before use of the product.

Yes Biofreeze is vegetarian friendly, no animal products are used in the ingredients. Biofreeze is also not animal tested.